Journals on Cancer Medicine

Abstract

#Cardiopulmonary bypass (CPB) is associated with common activation of all four integral components of hemostasis, that is, the endothelium, plasma proteins, platelets and #fibrinolysis. The causative factors include the presence of an artificial non-endothelial surface of the CPB system, non-pulsatile blood flow, #hemodilution, hypothermia, #surgical trauma and a systemic inflammatory response to CPB. Microthrombi formation, coagulation defects and hypercoagulability in the postoperative period may occur. The key pathway of activation is platelet binding to collagen via von Willebrand factor, platelet activation and aggregation and formation of an initial hemostatic plug. Thrombin generation (tF+fVIIa →fIXa →fXa →prothrombin →thrombin) activates platelets, fV, fVIII and fXI. Fibrinogen and fXIII stabilize the clot.

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Platelet Function during Platelet-Rich Plasma Sequestration in Complex #CardiacSurgicalProcedures - Prospective Controlled Study by Luděk Slavík in BJSTR