Abstract
Introduction: Brain-derived #neurotrophicfactor (BDNF) plays a
key role in promoting the survival of neurons in the nervous system.
#Polymorphism in the gene region 196G>A and 270C>T of BDNF has been
studied for susceptibility to Parkinson’s Disease (PD) but results from
different studies are inconclusive.
Objective: To carry out a meta-analysis and trial-sequential analysis of the previous studies to assess the relationship between the BDNF
196G>A and 270C>T polymorphism and PD risk.
Methods:The databases were searched for the studies concerning
BDNF 196G>A and 270C>T polymorphism and its association with PD
risk. The pooled odds ratios (ORs) along with 95% confidence intervals
(95% CIs) were calculated for all the genetic models, from the selected
case-control studies, by meta-analysis. The required information size
was calculated using α = 0.05 (two sided), β = 0.20 (power 80%) and a
relative risk reduction of 20%, by using trial sequential analysis (TSA)
Results: Results of present meta-analysis identified an
association between recessive AA Vs GG+AG genotype and PD in Asian
population
but no association between BDNF 196 G/A polymorphism and PD in European
population. On the other hand, association between BDNF 270
C/T allele in overall studies was observed for T Vs C allelic contrast
and dominant TT+TC Vs CC genotype.
Conclusion: Our meta-analysis demonstrate that the evidence for associations between BDNF polymorphisms (G196A and C270T) and PD
risk for few allele and genotype combinations are present but is ethnicity dependent.
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