Abstract
The #knee joint cartilage often suffers from defect and it causes
serious #health problem. CD34+ stem cells cells have been studied to heal
bone fracture however the cells has never been studied to repair
cartilage. This study also focuses on the use of scaffold and growth
factor affecting the healing of cartilage defect using CD34+ cells. This
is the first study reporting #hyaline cartilage regeneration on
#osteochondral defect with intra articular injection of human peripheral
blood CD34+ (HPB CD34+) cellated on the trochlear region of Sprague
Dawley (SD) rats. A total of 30 male SD rats were randomly divided into 3
groups; the control group received PBS, experimental group 1 received
HPB CD34+ cells, and experimental group 2 received HPB CD34+cells,
hyaluronic acid, and growth factors (TGF-ß1, IGF-1, FGF, fibronectin).
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