Abstract
#Morphine is an important #wanalgesic pain control for the patients. The
unwanted morphine analgesic tolerance limited its using. In this study,
we attempted to improve the effectiveness of morphine and delayed
morphine tolerance by intermittent administrations of morphine.
Moreover, we have designed a new composite for management of pain, e.g.
combination (GTPm) of green #teapolyphenols (GTP, 30 mg/kg/day) with
#memantine (3mg/kg/day). The results showed that morphine (I.P.
injection, 10 mg/kg/day) treated mice received morphine for consecutive
five days followed by two days’ off can maintain analgesic tail flick
test after long-term (54 days) administration of morphine.
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Week off Two days’ Model on Analgesic Efficacy of Chronic Administration of Morphine in Mice by Shoei-Yn Lin-Shiau in BJSTR
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