Journals on Medical Casereports - BJSTR Journal

Abstract

Aim: #Oral melanotic macule is a well-circumscribed pigmented lesion that commonly occurs in the oral mucosa. Histologically, it is characterized by increased production of melanin by #basalmelanocytes which present normal number and normal #morphologic features. Lesions may also exhibit melanin - laden macrophages in the adjacent lamina propria. Because of the benign #histological appearance, most authorities ignore its #pathogenesis. The purpose of the present study was to immunomorphologically characterize oral melanotic macules.

Materials and Methods: Cases of #oralmelanotic macule were included and compared with normal appearing margins of the lesion and as reactive hyperplastic lesions as controls. The morphological assessment was carried out by measurement of rete ridge lengths and by immunomorphometric analysis of the epithelial expressions of S100 and HMB45.

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Histomorphometric and Immunohistochemical Characteristics of Oral Melanotic Macule- Overlap with Oral Mucosal Lentigo by Irit Allon in BJSTR