Immunological diseases - BJSTR Journal

Abstract

The relationship between circadian rhythm and autonomous cortisol secretion of #adrenocortical lesions associated with #Cushing’s syndrome is still unknown. We show here that in Y1 adrenocortical tumor cells, circadian rhythm of Per2 mRNA expression was in a 24 h manner, while that of #steroidogenic-related genes such as P450scc mRNA and Ad4BP/SF-1 mRNA was asynchronous with Per 2 mRNA, compared to normal mouse adrenal primary culture tissue which show #synchronized expression of the three genes. #Deletion mutants of Ad4BP/SF-1 promoter activity in Y1 cells show that the E-box element functioned in a circadian-like pattern which was abrogated in promoter constructs which lack the E-box. Rhythm of upstream factor-1 (USF-1) mRNA correlated with Ad4BP/SF-1 mRNA expression, which is known to bind the E-box of Ad4BP/SF-1 promoter.

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Asynchronous Rhythm of Ad4BP/SF-1 and Per2 Expression in Adrenal Tumors of Cushing’s Syndrome by Kenji Ohe in BJSTR