Journal of Scientific and Technical Research - BJSTR Journal

Abstract

In the last years, the world of #cardiology has turned the lights on the role of #pro-inflammatory constellation of #cytokines and #interleukins in the #pathophysiology of myocardial and vascular damage. #Cardiomyocytes and vascular endothelial cells produce continuously several growth factors and small molecules, acting both in autocrine and paracrine manner, regulating their mitochondrial metabolism, the balance of intracellular calcium and also the resistance to chemotherapeutic damage. This review place same biological and biochemical basis on the involvement of the cardiac and vascular mirco environment on the cardiovascular diseases and on the #cardiotoxicity related to anticancer drug exposure, with particular reference to Interleukin 1, 6, 8, Advanced Glycation End Products and #lipid peroxidation. Moreover, some biological and clinical considerations will be discussed aimed to improve the cardiac and vascular microenvironment, also by using phytotherapics and anti-inflammatory drugs of synthetic or natural origin. Tissue and cellular microenvironment is a complex of interations between small molecules like interleukins, cytokines, chemokines, SIRNA, hormones acting in #autocrine and paracrine manner in cardiomyocytes [1]. The cardiac tissue is a pluricellular organ composed of cardiomyocytes, #fibroblasts, endothelial cells, #smooth muscle cells, neurons and immune cells regulating the homeostasis of the matrix deposition, neo-vascularization, inflammation and #mithocondrial metabolism [2].

For more articles on BJSTR Journal please click on https://biomedres.us/

For more Scientific and Technical Research Articles on BJSTR

https://biomedres.us/fulltexts/BJSTR.MS.ID.001523.php

Cardiac and Vascular Microenvironment: Biological and Clinical Implications in Cardiology by Nicola Maurea in BJSTR