Journal on Medical Genetics - BJSTR Journal

Abstract

#Narcolepsy is a disabling disorder characterized by recurrent daytime sleepiness and #cataplexy [1]. The 90% to 95% loss of #hypocretin (also called orexin) neurons in postmortem brains of narcolepsy is reported [2]. An immunological pathogenesis for the lack of hypocretin neurons in narcolepsy has been suggested in view of the tight association with the HLA-DQB1*0602 [3-4]. Recent findings including our research showed 16-26% of narcolepsy patients having #anti-tribbles pseudokinase 2 (TRIB2) #autoantibody in their blood [5-7]. However, it remains to be clarified whether or not causal relationship exists between anti-TRIB2 autoantibody and narcolepsy. TRIB2 is highly expressed not only in hypothalamic hypocretin neurons but also in visceral fat [8].

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Anti-Trib2 Autoantibody in Narcolepsy as A Result of Hypocretin/Orexin Nerve Deciduation by Susumu Tanaka in BJSTR