Abstract
Objective: To determine the #immunolocalization and cellular
expression of #adenosine triphosphate-binding cassette (ABC) proteins
viz. #breast cancer resistance protein (BCRP) and multidrug resistance
protein 1 (MDR1) in canine mammary tumour (CMT), as well as to correlate
their expression with the #histological subtypes and grades of CMT with a
view towards therapeutic implications.
Methods: Fifty-three cases of malignant CMT were included in
the study. The histological sections taken from archived paraffin blocks
were subjected to histopathology and imunohistochemistry for
sub-typing, grading, immunolocalization and cellular expression of BCRP
and MDR1 and their interrelation.
Results: Both BCRP and MDR1 were mainly immulocalized in
cellular membranes and to a lesser extent in the cytoplasm of the
cancerous epithelial cells and #stromal connective tissue.
#Carcinosarcomas followed by carcinomas and sarcomas revealed decreasing
expression of both BCRP and MDR1 proteins. A positive and an inverse
correlation between BCRP and MDR1 expression, respectively was observed
with the increasing grade of CMT.
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