Journals on Vaccination - BJSTR Journal

Abstract

In the mid1980s, Williams and his colleagues at the Harvard School of #Dental Medicine (HSDM), and Golub and his group at Stony Brook University (SBU), addressed the importance of the Host Modulation Therapy (HMT) in #periodontal disease by demonstrating

a) that non-steroidal anti-inflammatory drugs or #NSAIDs such as #flurbiprofen can inhibit alveolar bone loss in animal studies and in human clinical trials [1-4] and

b) that #Tetracyclines, by NON-antibacterial mechanisms can inhibit host-derived #Matrix metalloproteinases (MMPs) and osteoclast activity to suppress collagenase and bone resorption, processes essential for periodontal and other (e.g., Rheumatoid arthritis) diseases [5-7].

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Systemic Host Modulation Therapy in the Treatment of Periodontal Disease by Muna S Elburki in BJSTR