Abstract
In the mid1980s, Williams and his colleagues at the Harvard School of
#Dental Medicine (HSDM), and Golub and his group at Stony Brook
University (SBU), addressed the importance of the Host Modulation
Therapy (HMT) in #periodontal disease by demonstrating
a) that non-steroidal anti-inflammatory drugs or #NSAIDs such as #flurbiprofen can inhibit alveolar bone loss in animal studies and in
human clinical trials [1-4] and
b) that #Tetracyclines, by NON-antibacterial mechanisms can inhibit
host-derived #Matrix metalloproteinases (MMPs) and osteoclast activity to
suppress collagenase and bone resorption, processes essential for
periodontal and other (e.g., Rheumatoid arthritis) diseases [5-7].
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Systemic Host Modulation Therapy in the Treatment of Periodontal Disease by Muna S Elburki in BJSTR
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