Abstract
#Renal glucosuria (RG) is a disorder of #proximal tubular glucose transport, characterized by abnormal urinary excretion of glucose in the
absence of impaired glucose metabolism. In some affected families, RG
is caused by #homozygosity or compound #heterozygosity of mutations in the
SCL5A2 gene, encoding the renal-specific sodium/glucose cotransporter
2. Some children are detected as urine glucose positive with no evidence
of #hyperglycemia in a screening program at school, and are diagnosed as
having RG. We found about 30% of Japanese school students with a
positive result at a urine glucose screening program at school was
diagnosed with diabetes. On the other hand, the others, almost 70% of
cases, with positive urine glucose was finally identified as having RG
with no evidence of glucose intolerance in the detailed examination.
They had a strong family history of RG. We conclude that RG may be not
rare, but a frequent condition with #glucosuria among Japanese school
children.
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