Immunological Diseases - BJSTR Journal

Abstract

Some new pyrimidine derivatives have been synthesized and their #physicochemical parameters such as density, refractive index and conductance have been measured in N,N-dimethyl formamide and #tetrahydrofuran at 308.15 K. It is observed that solvent and structure of compounds have major effect on these studied properties which may be due to different type of interactions in different solvents for different compounds. Among many heterocyclic compounds, pyrimidine compounds are one of the most prominent structures which attract many chemists and pharmacists due to their therapeutic values [1-10]. The applications of these compounds in drug research have stimulated the invention of wide range of synthetic methods for their preparation and chemical transformations [11-15]. Further, many of these compounds are known to exist in #deoxyribonucleic acid and #ribonucleic acid which is one of the most essential constituents of all cells and thus of all living matter. As many of these compounds exist in various drugs [16-18], it would be useful to study their physical parameters which are prime factors for the study of these compounds in pharmaceutical field [19-21]. Thus, in the present work, #physicochemical parameters such as density, refractive index and conductance of some newly synthesized pyrimidine derivatives such as #dihydropyrimidine and #dihydropyrimidinthiones have been measured in N,N-dimethyl formamide, dimethylsulphoxide and tetrahydrofuran at 308.15 K.

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Measurement of Density, Refractive Index and Conductance of Some Pyrimidine Derivatives in Solutions at 308.15 K by Shipra Baluja in BJSTR