Journals on Medical Casereports - BJSTR Journal

Abstract

In chronic experiments on rabbits, we demonstrated that electrolytic destruction of the dorsal #amigdalofugal way - stria terminalis results in intense depression of the integral electrical activity of the hippocampus. Morphological changes in neurons and satellite glial cells, such as lysis of the Nissl substance, hyperchromatosis, and wrinkling of the cells after destruction of the #stria terminalis, were proof of the correctness of our conclusion. It is postulated that one of the main factors underlying the generalized effects observed in our experiments is probably the disturbance of functional characteristics of the #hypothalamo- hypophyseal neurosecretory system induced by destruction of the #amygdalofugal connections; this disturbance results in significant pathological shifts of metabolism in the hippocampus. The study of the hippocampal theta rhythm is one of the urgent problems of modern neurophysiology. The medial septum nucleus, standing at the entrance to the hippocampus, demonstrates the importance of this education [1,2]. In addition to the data indicative of the pacemaker role of the septum, there are works which demonstrated the a definite role of stem-diencephalic structures in mechanisms of formation of hippocampal theta rhythm: of great importance given to the reticular formation [3], the hypothalamus [4], the thalamus [5], locus cereleus [6], nucleus raphe [7], etc. In order to study the role of amygdalo- hypothalamic connections in the processes of formation of the hippocampal theta rhythm in this study was conducted electrical stimulation and destruction of the dorsal (DAP) and ventral amygdalofugal pathways (VAP). After #electrophysiological studies was conducted a morphological analysis in neurons and glial cells in various areas of the hippocampus and the medial nucleus of the septum.

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Participation of Amygdalo-Hypothalamic Connections in the Regulation of The #HippocampalThetaRhythm by Rafiga Mazahir Baghirova in BJSTR