Abstract
Roughly 22% of all pregnancies end in an abortion [1]. This rate goes
up to as much as 75% in pregnancies occurring in advanced age. Normally
once women seek counselling with bleeding in early pregnancy mostly the
standard method of finding viability has been clinical evaluation,
doing an #ultrasonography along with quantitative #HCG levels and repeated
USG for confirmation of a missed abortion causing loss of time and
emotional sequelae [2]. Robinson et al. [2] quoted that stress and #anxiety is worst at the time of initial knowledge than the depression
that follows the final miscarriage [2]. Garcia [3] reviewed the risk
factors for these. Importance of making an early diagnosis is that one
can stop the medications like P or oral anticoagulants, while those who
have an ongoing IUP, one can reassure the patient and observe her
medically. Recently based on the physiological knowledge that alpha protein (AFP)
is produced by yolk sac and later on by the fetal liver [4], as early as
the 5th week of #gestation, AFP can be measured from the
#embryonic tissue. In fetal serum AFP is>=1000 times higher than the
maternal serum [5]. Thus Mor [6] hypothesized if AFP concentration in
vaginal blood which contains dissolved fetus tissue is higher than #AFP concentrations in maternal serum. Thus, they tried to find if relatively
high AFP concentrations in early 1st trimester or early second
trimester vaginal blood will confirm the presence of an IUP which has
failed i.e. a missed abortion or incomplete abortion since it contains
dissolved fetal tissues [6].
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"Detection of Early Pregnancy Loss Using Vaginal Blood Alpha-Fetoprotein in the Pipeline" - A Short Commentary by Kulvinder Kochar Kaur in BJSTR
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