Neurological Disorders - BJSTR Journal

Abstract

In this paper the author describes the morphological and #immunohistochemical features of the most common benign epithelial lesions of the endometrium, which can be mistaken for neoplastic malignancies (#pseudoneoplastic lesions). In addition, here it was demonstrated that both morphologic clinical data and immunohistochemical features are useful for an accurate differential pathological diagnosis from non-neoplastic lesions and epithelial malignancies. In this paper the author describes the morphological and immunohistochemical features of the most common benign epithelial lesions of the endometrium, which can be mistaken for epithelial malignancies (pseudo-neoplastic lesions). The material used for this study was obtained from the archive of the Department of Medicine and Surgery, Pathology Unit, Parma University (Italy) and from a review of the literature. Relevant articles were obtained by searching the PubMed and MEDLINE databases. These databases were searched using the following key words: '#Pseudoneoplastic lesions of endometrium' and 'Mimics of malignancies of endometrium". Articles were considered if the studies included #clinico-pathological and immunohistochemical features of the lesions. Papers, which were not written in English, were excluded. On microscopic examination, many benign alterations of the endometrium can mimic malignant epithelial lesions. Also, clinically these lesions could suggest a diagnosis of malignancy since they are characterized by abnormal uterine bleeding and can be found in an endometrial biopsy. To make a correct diagnosis, in evaluating an endometrial biopsy specimen, adequate clinical data are important, such as the age of the patient, the reason for the biopsy, the menopausal status, the use of exogenous hormones, and a history of previous pregnancy or abortion. Placental site nodules [1-3] and endometrial epithelial metaplasia [4-6] represent the most common lesions that can be misdiagnosed as malignant epithelial lesions in an endometrial biopsy. A Placental Site Nodule (PSN) is a remnant of intermediate trophoblast (#extravillous trophoblast, EVT) from a previous pregnancy. Thus, it may be considered retained placental tissue in utero which does not undergo involution after pregnancy and may be detected many months or even several years after a previous pregnancy [1-3,7].

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Non-Neoplastic Lesions that may Mimic Epithelial Malignancies of the Endometrium: Morphological and Immunohistochemical Analysis by Giovanna Giordano in BJSTR