Biomedical Science Articles - BJSTR Journal

Abstract

While the advances in #revascularization therapy have drastically decreased the mortality following ST elevation #myocardial infarction (STEMI), the number of patients who develops #heart failure (HF) following the reperfusion therapy continues to rise. More than 30% of the patients who survive STEMI develop HF long term [1]. In addition, patients with a history of acute myocardial infarction (AMI) and left ventricular (LV) dysfunction have a markedly increased 6 months mortality of greater than 10% [2] Thus, there is an urgent unmet clinical need to clarify the mechanisms of SCD and HF post-MI and develop a #robust biomarker to identify the high-risk patients. The importance of differentiating the peri- infarct region (PIR) from the adjacent non-viable infarct core (IC) has been noted recently as it could independently determine the occurrence of major adverse clinical events [3,4]. The PIR consisting of heterogeneous tissue components represents the nexus for active remodeling or repair characterized by extracellular matrix formation, #angiogenesis, oxidative stress, mitochondrial energetics, apoptosis and inflammation [5,6]. We here review the non-invasive MRI approaches to characterize PIR.

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T1 Mapping for Quantifying Myocardial Viability in the Peri-Infarct Regions by Phillip C Yang in BJSTR