Journal on Medical Genetics - BJSTR Journal

Abstract

The study aimed to identify significant changes in specific paroxysmal EEG features at early infancy stages as indicators of late-infancy epileptic foci formation in an infant suffering from early-onset #epileptic encephalopathy. Early infancy EEG was recorded for 90 minutes at ages four, and seven months. At late infancy, video-EEG was recorded for 8 hours at age 23 months. Early and late-infancy EEG data was visually analyzed for seizure-related epileptic discharges, including the assessment of slow-wave spikes frequency and their topography at early infancy, and identification of seizure- related spectral power density changes, and their most #dominant semiology, at late-infancy. Statistically significant age-dependent differences in interictal slow-wave-spike frequency at parietal cortex locations during early-infancy were consistent with parietal cortex epileptic foci dominance at late infancy. The results support developmental age-dependent EEG assessments in detecting significant paroxysmal location-specific changes of slow-wave spike frequency in early-infancy as indicators of epileptic foci-dominance and progression in early-onset epileptic encephalopathy. Replication of our findings in other #neonatal electroclinical syndrome cases that suffer from seizure intractability is likely to propagate early focal treatment interventions to inhibit location-specific paroxysmal epileptiform activity in #neonatal catastrophic epilepsies.

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Age-Dependent Changes in Spike Frequency Putatively Predate Epileptic Foci Formation in Neonatal Epileptic Encephalopathy by Oded Meiron in BJSTR