Journal on Medical Genetics - BJSTR Journal

Abstract

Introduction: #Tricyclic antidepressants are used in multiple #psychiatric disorders such as depressive syndrome or attention deficit hyperactivity disorder. #Acute intoxications by this drug if not treated in time, have a high mortality due to the cardiovascular effects that occur in the body.

Objective: Detect acute poisoning by tricyclic antidepressants with the analytical values in serum of patients who have symptoms compatible to establish treatment early.

Method: Review of the clinical history of patients who in the urine drug screening test were positive for tricyclic antidepressants and had a compatible electrocardiogram. Venous blood samples were processed in Cobas 6000 e501 (#Roche Dignostics) by the #homogeneous enzyme immunoassay technique.

Results: Differentiation in 3 groups of patients according to the plasma concentration values.

Conclusions: The quantification of the plasma concentration of tricyclic antidepressants offers additional information to confirm the diagnosis but not for the urgent treatment of these intoxicates because the free concentration of the drug is modified with pH or the individual variability.

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Clinical #Manifestations in Intoxications by Tricyclic Antidepressants by A Fernandez Ibanez in BJSTR