Abstract
Objective: To evaluate the effects of low-level laser therapy
and extract of #Calendula officinalis Linn. (calendula), alone or in
combination, on cutaneous wound healing in rats.
Setting: A university research center.
Design: A prospective, interventional, randomized, controlled
experimental study. Forty-eight female #Wistar rats, aged 3 to 4 months,
were divided into 4 groups of 12 animals each. A skin wound was
surgically made in the dorsal region of each animal and treated for 21
days with either low-level laser therapy (laser group), calendula
extract gel (calendula group), laser therapy combined with calendula
extract gel (laser + calendula group) or received no treatment (control
group). Data collection was performed immediately after surgery and on #postoperative days 3, 6, 9, 12, 15, 18 and 21.
Main Outcome Measures: Measurement of the wound area was
performed by tracing the contour of the wound on a #sterile polypropylene film placed over the wound. The drawing was transferred to the Auto Cad
software to determine the size of the wound area.
Results: No significant differences in wound area size were
found among groups up to the postoperative day 6. After 9 days of
treatment, the laser group showed a significantly greater reduction in
wound area compared to the other groups.
Conclusion: Laser therapy alone contributed more to wound
healing in rats than the treatment with calendula extract gel alone or
combined with laser therapy.
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The Effect of Low-level Laser Therapy and Calendula Officinalis Linn. On Cutaneous Wound Healing in Rats by Geraldo Magela Salome in BJSTR
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