Journals on Medical Casereports - BJSTR Journal

Abstract

#Dengue (DENV) and Zika virus (ZIKV) are very close relatives belonging to the Flavivirus family and thus share many structural and antigenic features, as well as their infectious cycle. Both viruses are transmitted to humans through mosquito bites mainly from #Aedes genus (Ae. aegypti and Ae. albopictus) [1], which have been expanded their habitats to an extent that half the World's population is now at risk of DENV/ZIKV infection. The most severe consequences of having either virus would be dengue shock syndrome which normally leads to death [2], or in the case of ZIKV, microcephaly in newborns from infected mothers and Gillian- Barre syndrome [3-4]. For DENV, it has been well documented that a second infection with a different #serotype, increases the chance of having the most severe dengue form, through a mechanism called antibody-dependent enhancement (ADE) [5], a phenomenon which has not been related in ZIKV infection in patients previously exposed to DENV or other #Flaviviruses [6]. The fatal consequences, along with the lack of an effective treatment, have pushed forward a great effort from several research groups to develop vaccines against DENV, and it seems that some key learnings from DENV have accelerated the development for ZIKV vaccines. A vaccine candidate comprising a mixture of four populations of chimeric viruses, each for a different #DENV serotype (tetravalent), having the non-structural proteins from yellow fever virus and structural proteins from DENV, reached phase III clinical trial; unfortunately, the trial results were not as expected, since protection against DENV-2 was not good enough and most important, children that had not been infected with DENV before vaccination, were more susceptible to develop severe dengue symptoms in a subsequent DENV infection [7-8].

For more articles on BJSTR Journal please click on https://biomedres.us/

For more Biomedical Intervention Articles on BJSTR

https://biomedres.us/fulltexts/BJSTR.MS.ID.001653.php

Challenges for the Development of #Dengue and Zika Virus Vaccines by Darwin Elizondo Quiroga in BJSTR