Abstract
Objective: #Cervical intraepithelial neoplasia (CIN) frequently
affects young women in childbearing age. Present literature does not
provide scientific consensus on the real incidence of obstetric
complications after the various conservative techniques performed. Most
of all literature data are still lacking a pathophysiological basis to
explain the different impact of various treatment techniques on the
functional integrity of the uterine cervix. The gold standard
conservative treatment is the excisional therapy. This study tried to
analyze the evolution of tissue repair of cervix subjected to CO2
laser conization for high grade CIN with the aim of identifying
eventual differences between the repaired tissue and the original
cervical one.
Study Design: The analysis was conducted on #histological seriated samples of #uterine cervix obtained at standardized times after
conization treatments and then analyzed using histological examination
and #immunohistochemical staining.
Results: This study showed that the tissue concentration of TGF01 was significantly low in patients treated with CO2
laser, confirming the reduced inflammatory reaction after laser
treatment. Another very interesting result was the high ratio of type
III and type I collagen: the prevalence of type III collagen suggested a
regeneration of tissue without scarring after laser therapy.
Conclusion: Tissue repair process after CO2 laser
cervical treatment is able to compensate the loss of substance in
damaged area and at the same time to limit the deposition of
disorganized connective matrix, typical of scars, leading to a
morphologic and #functional restitutio ad integrum of the treated
cervical tissue, which tends to be similar to the original one.
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