Abstract
The application of nanotechnology in the medical field has been
growing year by year, reflecting the advances of #nanomaterials as #theranostic agents for the detection and treatment of diseases,
especially in oncology. However, there are several barriers that inhibit
the efficiency in the use of these materials for medical applications,
for example, opsonization and phagocytosis processes, low
#biodistribution, and especially, lack of specificity and selectivity.
Natural cell membrane nanoparticle coating is one of the newest and most
innovative strategies for solving such problems by offering highly
selective surfaces that are difficult to achieve using traditional
synthetic products. Combined with advances in nanoparticle camouflage
are drug delivery and therapies, as #photothermal, which makes use of the
surface plasmon resonance effect of nanoparticles to generate a rapid
localized heating, ideal for favoring the death of cancer cells. In this
context, the emphasis of this mini review is presenting some successful
research in #theranostic nanomaterials camouflaged with cell membranes
for therapies and delivery. In the last years, numerous studies have focused on improving
nanomaterials to be applied as theranostics agents for cancer therapy;
some design strategies to obtain this was illustrated in Figure 1. But
the therapeutic efficacy of nanomaterials is still a challenge in
nanomedicine due to poor delivery route and biodistribution. It is a
consensus in the area, no matter what type of surface functionalization,
active or passive, more than 99% of nanoparticles administered invivo
are phagocytized by the #biosystem. However, these problems have been
apparently solved by the use of natural cell membrane coating the
surface of nanomaterials.
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