Abstract
Patients with long term dry eye (DE) could suffer cornea damage. To
date, there is no universal diagnostic test to detect eye dryness.
Recently, an automated diagnostic method of DE using #thermographic images provided a good binary classification between normal and DE
subjects. The present work focuses on the automatic diagnosis of DE
patients using #tear ferning (TF) images. The TF images for 100 subjects
were used to classify their degree of dryness automatically (without
#human interaction) using a five-point grading scale. First, from each TF
image a vector characteristic (VC) was computed to represent each
patient during the automatic classification. Then, it was compared to
the VC references representing the five points grading scale. Next, each
subject's TF image was assigned to the closest reference. The
classification of each patient's degree of dryness using the vector
characteristic is based on a decision tree approach using "See5”: tools
for data mining that generates decision trees for classification
purpose. The fully automatic classification (diagnosis) provides a
promising result compared to the manual classification by two experts.
It was found that 81% of the automatic classification perfectly matched
the manual ones. 12% of the automatic grades were misclassified to the
next grade (i.e. one grade difference between the automatic and #manual grading). Only 7% were completely misclassified. Future work on the VC
and the algorithm of classification using #synthetic TF images could
further improve the automatic classification of dry eye patients.
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