Open Access Clinical and Medical Journal - BJSTR Journal

Abstract

Introduction: This study aimed to investigate the predictive value of #preoperative serum cystatin C (S-cystatin C), in identifying patients whom at higher risk of acute kidney injury after cardiac surgery (AKI).

Methods: To predict the early mortality, we used the European system for cardiac operative risk evaluation (EuroSCORE). #Serum creatinine levels on admission were used to evaluate the glomerular filtration rate (GFR) by using the Modification of Diet in Renal Disease (MDRD) equation. S-cystatin C, NT proBNP and #procalcitonin were measured before cardiac surgery (H0), 4 hours after the end (H4) and every day during the first two days (H24, H48). All patients were followed during a whole year.

Results: Positive associations were observed between #baseline s-cystatin C value and EuroSCORE and with RIFLE classification. Different positive correlations were observed between baseline s-cystatin C, cardiac markers and procalcitonin. A preoperative s-cystatin C cutoff 1.025 mg/L demonstrated higher sensitivity than preoperative s-creat cutoff, in discriminatory accuracy of one-year mortality. Estimated GFR, #procalcitonin and NT proBNP showed a decreased AUC values compared to s-cystatin After multivariate analysis, S-cystatin C and NT proBNP were independently associated with cardiovascular events accuracy and re-hospitalization risk after cardiac surgery.

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Predictive Value of Baseline Cystatin C for Acute Kidney Injury after Cardiac Surgery by Manel Naifar in BJSTR