Journals on Biopsychological Medicine - BJSTR Journal

Abstract

Although #melatonin has been shown to be involved in the aging process and as a therapeutic target during normal aging, it is yet to be widely accepted as a #therapeutic target for age related vulnerabilities. With more evidences being unraveled from different studies, important lifestyle changes that will optimize its normal synthesis could be beneficial for the human population. Aaron Lerner and colleagues discovered melatonin in 1958 and the chemical structure was described in 1959 as N-acetyl- 5-methoxytryptamine [1]. #Melatonin is endogenously produced majorly in the #pineal gland especially at night. Melatonin is one of the strongest antioxidants known; it scavenges hydroxyl and peroxyl radicals [2,3]. Melatonin has a strong relationship with aging, the loss of melatonin in old age may contribute to the severity and incidence of #neurodegenerative diseases such as #Alzheimer's disease [4]. Armstrong and Redman in 1991 suggested that melatonin might have beneficial effects in aging because of its association with the circadian timing system [5].

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Melatonin, Mitochondria and Successful Aging by Idowu Abimbola John in BJSTR