Journals on Biotechnology - BJSTR Journal

Abstract

#Colorectal cancer (CRC) is the third most common malignancy worldwide, with an estimated one million new cases and a half million deaths each year. Screening for CRC allows early stage diagnosis of the #malignancy and potentially reduces disease mortality. The convenient and inexpensive #fecal occult blood test (FOBT) screening test has low sensitivity and requires dietary restriction, which impedes compliance and use. Although #colonoscopy. Considered as the golden standard for the screening for this cancer, the invasive nature, abdominal pain and high cost have hampered worldwide application of this procedure. A noninvasive sensitive screen for colon cancer (CC) requiring no dietary restriction is a more convenient test. CC is more abundant in the USA than rectal cancer (RC). The discovery of small noncoding protein sequences, 17-27 #nucleotides long RNAs (such as microRNAs), has opened new opportunities for a non-invasive test for early diagnosis of many cancers.#MiRNA functions seem to regulate development and apoptosis, and specific miRNAs are critical in #oncogenesis, effective in classifying solid and liquid tumors, and serve as oncogenes or suppressor genes. MiRNA genes are frequently located at #fragile sites, as well as minimal regions of loss of #heterozygosity, or amplification of common break-point regions, suggesting their involvement in carcinogenesis.

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Digital PCR Absolute Quantification of Micro RNAs for The Noninvasive Diagnostic Screening of Colon Cancer in Humans by Farid E Ahmed in BJSTR