Journals on Cancer Medicine - BJSTR Journal

Abstract

Soft Tissue #Sarcoma (STS) is a rare neoplasm that accounts for 1% of all solid tumors in adults. In 2013, 11410 new cases were diagnosed in adults and children in the United States with 4,390 expected deaths [1]. In more than 50 to 60% of the cases, limbs are involved and it can have more than 50 #histological subtypes [2] . These tumors are invasive and their metastasis risk is high [3] . Today, the treatment of sarcomas often includes a combination of surgery, #radiotherapy and chemotherapy [3]. However, there are extensive disputes and challenges regarding the use of chemotherapy and radiotherapy in these patients. Some studies have adopted optional chemotherapy treatment as an adjunct to increase the chance of preserving a limb, but the use of this method has not had a significant effect on overall survival [4].Other studies have suggested that in patients for whom the tumor cannot be removed completely by #surgery, to increase the chance #oftumor necrosis considering its high survival, a neoadjuvant chemotherapy treatment with #hypofractionated radiotherapy or in some cases adjuvant #chemotherapy, depending on the living cells, has been recommended. These methods have been able to improve patient complications and induce a pathologic response [4].

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Neoadjuvant Radiotherapy for Soft Tissue Sarcoma by Mirkazemi Masoud in BJSTR