Journals on Medical Genetics - BJSTR Journal

Abstract

Nickel is a naturally occurring heavy metal in the environment, and one of the harmful compounds found in tobacco, as it accumulates in the plant #Nicotina tabacum. It is also considered a carcinogen in humans. Its concentrations in the body can undergo many variations and its determination in body fluids can be an important way to monitor exposure to this carcinogen. This paper aimed to analyze salivary and blood nickel concentrations in smokers and nonsmokers. Salivary/blood concentrations of 23 individuals were determined by #graphite furnace atomic absorption spectroscopy. We found higher nickel salivary concentration in non-smokers (8.28 μg.L^-1 versus 4.23μg.L^-1), While blood concentration was greater in smokers (2.22μg.L^-1 versus 1.02μg.L^-1) (p<0.05, #Wilcoxon signed-rank test).Salivary concentration was 3.5 times higher in saliva than in blood, with no statistical correlation between the samples. Although #saliva is considered a good biological matrix, easy to collect/store, allowing the detection of nickel with the same technique already used for blood, it was not a suitable substrate for estimating the concentration of #nickel in the blood. In addition, unexpectedly, greater amounts of nickel were found in the saliva of nonsmoking individuals possibly resulting from nickel sources other than smoking.

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Correlation Between Salivary and Blood Nickel Concentration in Smokers and Nonsmokers by Daniel, Filipe Ivan in BJSTR