Journals on Medical Genetics - BJSTR Journal

Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors. There are many risk factors involved in CRC. According to recent findings,#Fusobacterium nucleatum (F. nucleaum) are closely related to the progression of CRC. Studies have found that F. nucleaum may contribute to the development and #prognosis of inflammation and CRC. The factors of the #pathogenicity of F #nucleaum include its adhesion, its metabolite butyric acid, the cell factor of the host, and so on. Underlying mechanisms of F. nucleatum in CRC remain to be established.#Colorectal cancer (CRC) is one of the most common malignant tumors [1]. Intestinal microorganisms can affect the development of intestinal tumors by regulating the proliferation and differentiation of intestinal epithelial cells, providing nutrition, participating in #angiogenesis and apoptosis [2-6]. In recent years, more and more evidences have shown that some #Fusobacterium, especially Fusobacterium nucleatum (F. nucleaum), are closely related to the progression of CRC. F. nucleaum, gram-negative obligate anaerobe, periodontal pathogenic bacteria, widely exists in the dental plaque #biofilm, which plays an important role in the formation, metabolism and succession of biofilm. F. nucleaum is invasive, adhesive and #proinflammatory, and has a high detection rate in oral and systemic infectious diseases [7].

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The Roles for Fusobacterium Nucleatum in Human Colorectal Carcinogenesis by Xiang li in BJSTR