Abstract
#Ulcerative colitis (NSU) refers to the number of diffuse chronic
recidivating diseases of the colon, which mainly affected its mucous
membrane. Some patients of disease are extremely #ma-lignant, with the
development of #segmental necrosis as thin and thick intestines [1-5].
NSU meets throughout the world. In year 3 to 15 of diagnosed new
observations on 100 000 of the population, and the incidence of reaches
50-80. Men and women have equally often. The first peak of the
delectability of age from 20 years old do40, the second 60-70 years
[2,6]. At pre-sent, there is no clear information about the etiology and
pathogenesis of this disease. It is expected that the development of
ulcerative colitis is the breakdown of immunological tolerance to
intestinal antigens. The result is a loss of immunological control of
inflammation in the wall of the small and large intestines [2,7]. It is
believed that this #pathological process normally resist low doses of
endogenous gljukokortikosteroidov (GKS), that in a cage are associated
with the specific gljukokortikosteroidnymi #zitoplazmaticakimi receptors.This complex enters the nucleus of the cell and is in contact with DNA
elements in the region are #glukokortikoida specific genes. The most
often considered to be a hereditary predisposition to the development of
autoimmune inflammation in the #mucosa of the colon in response to
sowing surface micro-organisms and #viruses, as well as contact the
impact food. This opinion is based on the frequent combination of NSU
with other autoimmune processes [3,8].
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Segmental Circular Necrosis of The Bowel by Shaposhnikov Veniamin Ivanovich in BJSTR
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