Journal on Biomedical Imaging - BJSTR Journal

Abstract

#Epidemiological studies have found that cervical cancer is closely related to human #papilloma virus (HPV) infection, probably due to genetic damage of cells and integration of high-risk HPV- DNA [1]. Studies have shown that PI3K/Akt signal is over-activated in various human squamous cell carcinomas associated with HPV infection. This conclusion has been further confirmed in cervical cancer. Abnormal activation of this pathway and HPV-encoded E-series #carcinogens have been reported to play a synergistic role in promoting malignant transformation of cervical cells [2]. transfected cervical cancer cells with E5 gene and found that E5 protein could up-regulate the expression of vascular #endothelial growth factor by activating PI3K/Akt signal [3]. Transfected cervical cancer HeLa cells with lentiviral vector carrying siRNA of HPV18-E6 gene. It was found that inhibition of E6 protein expression could significantly down-regulate Akt expression at mRNA and protein levels, effectively inhibiting the growth of HeLa cells [4].It was also found that over-activation of mTOR could inactivate the #phosphorylation of 4EBPl, the downstream target of mTOR, up-regulate the level of E7 mRNA cap-dependent translation and maintain the high expression of E7 protein. In turn, E7 protein could increase the level of Akt phosphorylation and maintain the survival of tumor cells by inhibiting Bax, the precursor of #apoptosis (Figure 1). 

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Effect of Fucoxanthin on PI3K/Akt Signaling Pathway in Human Cervical Cancer HeLa Cells by Guo Liu YE in BJSTR