Journals on Biomedical Engineering - BJSTR Journal

Abstract

Skin epidermis is made up of stratified epithelium. Stratification plays an important role during epidermal development. Asymmetric cell division occurs in the single layer of basal cells followed by stratification leads to production of committed #suprabasal during epidermal development. Suprabasal cells thus formed are immature and have to undergo cell divisions many times to form fully stratified #epithelia. There is a balance between cell growth and cell death due to homeostasis, which plays a vital role in development and maintenance of #multicellular organisms. #Homeostasis is controlled by various molecular mechanisms including apoptosis. UVB irradiation generally causes DNA damage leading to activation of the intrinsic cell death pathway which includes mitochondrial damage and #cytochrome c release in a receptor-independent way Cellular proteins such as p53 and Bax play major role in the intrinsic pathway whereas mitochondria promote apoptosis by controlling #apoptosome-mediated activation of caspase-9. Apoptosis is generally defined as programmed cell death responsible for elimination of damaged and redundant cells by activation of various type of caspases such as #aspartate-specific and cysteine #proteases. Caspases cleave important proteins, leading to fragmentation of cells into vesicles that can undergo #phagocytosis.

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BH3 Only Proteins as Major Player in Treatment of Skin Melanoma by Jyoti Vakhlu in BJSTR