Journals on Biomedical Engineering - BJSTR Journal

Abstract

#Cyclodextrins (CDs), a family of #macrocyclic oligosaccharides, are well known as drug carriers due to their specific structures and properties. Their adequate size and truncated cone-shaped architecture with inner slightly hydrophobic cavity and outer hydrophilic surface provide suitable space for interaction with many types of organic and inorganic compounds, including ions, proteins and oligonucleotides. The most common members of this family, a-CD, p-CD and y-CD, which are termed parent CDs, possess 6, 7 and 8 a-#D-glucopyranose units respectively. Among them, p-CD is able to form inclusion complexes with most of drugs, thanks to its medium-size inner cavity. As a result of their attributes in improving solubility, stability and #bioavailability of guest molecules, CDs are widely used in pharmaceutical applications. All these useful properties can be further enhanced by employing water soluble derivatives of CDs, such as hydroxypropyl and #sulfobutyl ether CDs. Benefiting from self-assembly and #supramolecular host-guest interactions, CD-based inclusion complexes can result in different nanoarchitectures which endow improved characteristics as higher loading capacity, targeted and controlled release.

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Smart Cyclodextrin-Based Drug Delivery Systems: Stimuli-Responsiveness and Controlled Release by Fabrizio Caldera in BJSTR 

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