Abstract
#Cyclodextrins (CDs), a family of #macrocyclic oligosaccharides, are well
known as drug carriers due to their specific structures and properties.
Their adequate size and truncated cone-shaped architecture with inner
slightly hydrophobic cavity and outer hydrophilic surface provide
suitable space for interaction with many types of organic and inorganic
compounds, including ions, proteins and oligonucleotides. The most
common members of this family, a-CD, p-CD and y-CD, which are termed
parent CDs, possess 6, 7 and 8 a-#D-glucopyranose units respectively.
Among them, p-CD is able to form inclusion complexes with most of drugs,
thanks to its medium-size inner cavity. As a result of their attributes
in improving solubility, stability and #bioavailability of guest
molecules, CDs are widely used in pharmaceutical applications. All these
useful properties can be further enhanced by employing water soluble
derivatives of CDs, such as hydroxypropyl and #sulfobutyl ether CDs.
Benefiting from self-assembly and #supramolecular host-guest
interactions, CD-based inclusion complexes can result in different
nanoarchitectures which endow improved characteristics as higher loading
capacity, targeted and controlled release.
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Smart Cyclodextrin-Based Drug Delivery Systems: Stimuli-Responsiveness and Controlled Release by Fabrizio Caldera in BJSTR
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