Journals on Medical Microbiology - BJSTR Journal

Abstract

Steroid myopathy is a consequence of #glucocorticoid administration and excess occurring in #Cushing's syndrome. It is characterized by muscle weakness, which impairs patients' capacity to perform everyday activities. The relevance of steroid myopathy is very high especially given the large number of patients suffering from inflammatory diseases that are treated with glucocorticoids. The major #pathogenetic mechanisms hypothesized are: imbalance between protein synthesis and degradation, impairment of mitochondrial function and redox imbalance. The triggers of the latter phenomena and muscle damage are still unknown. The latter issues are still unsatisfactorily settled mainly because analyses are mostly focused at times when steroid myopathy had fully developed making it difficult to take apart the phenomena causing the #myopathy from those being a consequence of it. To identify the triggering mechanisms involved in the pathogenesis of steroid myopathy the very early stages of the phenomenon must be investigated. This short review describes the effect of short-term #corticosteroid administration on muscle functional, structural and molecular adaptations in humans and mice.This short review will focus on to the understanding the pathogenesis of the steroid myopathy.

For more articles on BJSTR Journal please click on https://biomedres.us/

For more Medical Microbiology Articles on BJSTR

https://biomedres.us/fulltexts/BJSTR.MS.ID.001889.php

Steroid Myopathy: Understanding the Pathogenesis by Monica Canepari in BJSTR

Follow on Twitter : https://twitter.com/Biomedres01

Follow on Tumbler: https://biomedres.tumblr.com/

Like Our Pins On : https://www.pinterest.com/biomedres/