Sunday, January 5, 2020

Journals on Medical Genetics - BJSTR Journal

Abstract

Objective: Since magnetic resonance #imaging (MRI) became central in the diagnosis and follow-up of Multiple Sclerosis (MS), evoked potentials (EP) studies appear to have lost their value, despite their ability to indicate the real-time status of the #physiological system, and the nature of the lesion. In this study, we investigated the diagnostic utility of EPs and their correlation with MRI findings in our patients who were evaluated for suspected MS.
Materials and Methods: In this study, the medical records at first admission of 100 patients who were evaluated for suspected MS were analyzed retrospectively. The correlations of EPs with clinical and MRI findings were analyzed.
Results: The VEP test was more sensitive than orbital MRI in detecting optic nerve involvement. tSEP agreed with 81% of the MRI findings and mSEP with 55%. On the other hand, in patients with normal spinal MRI, mSEP and tSEP indicated functional impairment in 44% and 67% of the cases, respectively. Although MRI seems to be more useful in detecting brainstem abnormalities, only the BAEP study revealed subclinical involvement in 12% of the patients. Again, VEP indicated #subclinical involvement in 18% and mSEP in 29% of the cases. 

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