Abstract
Bateriophages, natural killers of bacteria, are nowadays interesting
tools in biomedical fields. Indeed, phages can be used in prevention,
diagnosis, and as treatment against bacterial diseases. Interestingly,
new phage technology allow them to be used against other #pathogens like
fungi and other viruses. Going beyond, #bacteriophages can be even
modified to specifically treat tumour cells. The large potential of
phages as biomedical tools is increasing, thanks to their easy
manipulation, high specificity, and low production cost. Nevertheless,
ethical concerns and regulatory protocols should be revised in order to
give trust to these applications and increase the general acceptance. Bacteriophages, also known as phages, are natural predators of bacteria.
Phages were discovered one century ago by Frederick Twort [1] and Felix
d'Herelle [2] independently. After their discovery, phages were
commonly used as therapeutic tools and successfully used to treat
bacterial diseases, as #dysenthery and cholera. Unfortunately,
antibiotics were rapidly spread as main treatment and phage therapy was
restricted to Eastern countries, were antibiotics were not allowed [3].
#Phages\ present an enormous diversity compared with other organisms.
Their particles contain nucleic acid (RNA or DNA), single o double
stranded, circular or linear, segmented or unsegmented, and large number
of #morphologies have been observed.
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Phages as Promising Biomedical Tools by Pilar Domingo Calap in BJSTR
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