Effects of the Aqueous Extract of #Cnestis Ferruginea on the Histological Structure of #Female Rat Ovary and Uterine Horns by Zougrou N’guessan Ernest in BJSTR
Abstract
Cnestis Ferruginea (Connaraceae) is a plant used in the treatment of several affections including “sterility” and increased fertility. This work
aims to show the pharmacological effects of the aqueous extract of Cnestis Ferruginea
on the ovary and uterine horn of adult female rats. Thirty six
adult female rats were randomized into 2 sets of 18 each and treated for
15 (set I) and 30 days (set II). Each set was then divided equally into
three groups. Group 1 (control) was orally administered with distilled
water once a day. Group 2 and group 3 were respectively treated with 50
(AECF50) and 100 mg/kg (AECF100) body weight of aqueous extract of C. ferruginea
orally once a day. 24 hours after the last doses, the rats of
each group are sacrificed. The ovary and uterus of each rat are removed
and immediately fixed in 10% formalin for histological study. Cnestis
ferruginea induced a significant (p <0.05) increase in the number of
corpus luteum after 15 days of treatment with AECF100. After
30 days of
treatment, the number of corpus luteum increased significantly (p
<0.05) with both doses administered. Both doses also induced
significant
increases (p <0.05) with the two treatment durations, the number of
De Graaf follicles. The number of tertiary follicles increased
significantly
(p <0.05) with AECF100 after 15 days of treatment. The duration of 30 days allowed recording a significant increase in the number of tertiary
follicles with the two doses administered. The other follicles experienced significant increases with AECF100
after 30 days of treatment. For
uterine horns, lumen diameters of uterine horns and uterine glands
increased significantly (p <0.05) with both doses administered and
both
durations of treatment. The thickness of the endometrial and the size of
the epithelial cells increased significantly (p <0.05) with AECF100
after 15 days of treatment. These latter parameters experienced
significant increases with both doses administered at the end of 30 days
of treatment. In conclusion, C. ferruginea stimulates folliculogenesis and induces ovulation in the ovary. On the uterine horn, this plant has
estrogenic properties.
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