Expression of #Vascular Endothelial Growth Factor-C in #Oral Squamous Cell Carcinoma: An I#mmunohistochemical Study by Rakia Sahaf in BJSTR
Abstract
Background: Oral squamous cell carcinoma (OSCC) is globally
one of the most frequently reported malignancies characterized by local
invasion and distant metastasis. Lymphangiogenesis facilitates invasion
and nodal metastasis, and vascular endothelial growth factor C
(VEGF-C) has been implicated as a key mediator of this process. The
current study aimed at determining VEGF-C expression in OSCC and its
association with Clinicopathological parameters and lymph node
metastasis in our population.
Methods: Biopsies from 110 OSCC patients, with detailed
documentation of their clinical data were included. After histological
examination,
cases were evaluated by immunohistochemistry for VEGF-C expression.
Reactions were quantified and relation with Clinicopathological
parameters explored. The data was analysed using SPSS 21.0.
Results: Mean age of the patients was 59.91 ± 1.36 years with
the male to female ratio being 1.2:1. OSCC was commonly associated
with smoking (30.9%). Immunohistochemical staining of the histological
tissue sections of all cases of well (n= 42), moderate (n = 38) and
poorly differentiated OSCC (n = 30) revealed extensive VEGF-C
immunopositivity compared to normal Keratinocytes. VEGF-C expression was
associated significantly with clinical variables (P < 0.05), lymph
node metastasis (P <0.004) and the degree of differentiation of the
tumour(P<0.001).
Conclusion: The findings of the current study underscore the
significance of VEGF-C expression in relation to oral carcinogenesis and
lymph node metastasis, thereby highlighting its potential for being a
promising target for antibody-based therapeutic strategies in Pakistan
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