Effects
of Pulsed Electromagnetic Fields on Peripheral Nerve Regeneration Using
Allografts in Sciatic Nerve: An Animal Model Study by Payman Tavakoli in BJSTR
Abstract
Current gold standard for the clinical treatment of severe peripheral
nerve damage involves using an autologous nerve to bridge the defect
in injured nerve. Effects of pulsed electromagnetic fields (PEMF) on
nerve regeneration were studied using allograft in a rat sciatic nerve
model. Thirty male white Wistar rats were randomized into three
experimental groups (n = 10): Normal group, allograft group, and PEMF
treated group. In normal group left sciatic nerve was exposed and after
homeostasis muscle was sutured. In the allograft group the left sciatic
nerve was exposed through a gluteal muscle incision and transected
proximal to the tibio-peroneal bifurcation where a 10 mm segment was
excised. The same procedure was performed in the PEMF group. The
harvested nerves of the rats of allograft group were served as allograft
for PEMF group and vice versa. The PEMF group the whole body was exposed
to PEMF (0.3 mT, 2Hz) for 4h/day within 1-5 days. Behavioral
testing, sciatic nerve functional study, gastrocnemius muscle mass
showed earlier regeneration of axons in PEMF than in allograft group (p
<
0.05). Whole body exposure to PEMF improved functional recovery and
morphometric indices of sciatic nerve. PEMF could be considered as an
effective, safe and tolerable treatment for peripheral nerve repair and
may have clinical implications for the surgical management of patients
after nerve allografting.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.