Prognosis Comparison Molecular Subtype Breast Cancer between Young and Adult Women at General Hospital Dr. M Djamil Padang by Azamris in BJSTR
Abstract
Breast cancer is a heterogenic disease with various biologic profiles
and clinical prognosis. A research in Netherland by Esther, et al 2013,
showed that molecular subtypes of breast cancer have different
distribution and prognostic between young and adult, but there is no
local and
national data.A Comparative research with cross sectional design was
Held in January-April 2015 with 96 samples of breast cancer women
with age < 40 years old and > 40 years old, recorded in medical
records and breast cancer registrated from 2012-2014. Young women Breast
cancer at General Hospital Dr. M. Djamil Padang for 3 years (2012-2014)
are 27.1% and the adult are 72.9%. In bivariate analysis, there are
no relationship between characteristics of tumor with recurrent and
death event while in the adult women breast cancer, tumor size and
metastases have relation with recurrent and death event that are
statistically significant. There are different characteristics and
description of
molecular subtype breast cancer between young and adult women, young
ages are tend to have big tumor, lymph node positive, lympovascular
invasion, high grade tumor, proliferation index Ki67 high and negative
hormone receptor. There are different tendency of prognosis women
breast cancer between young and adult based on molecular subtype but
statistically, the relationship is not significant.
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