Abstract
Hormone receptors that are classically located in either cytosol or
nucleus or in the plasma membrane are also found in mitochondria.
Notably, they belong to different categories, such as proteins mainly
known as hormone-dependent transcription factors, receptor tyrosine
kinases, multimeric ligand-gated ion channels, and G protein-coupled
receptors. Some of them represent mitochondrial variants, whereas
others seem to be almost or fully identical with the extra mitochondrial
forms. In some cases, mitochondrial receptors are associated with the
outer membrane, whereas others are integrated in the inner membrane and
act by signaling towards the matrix. In functional terms, some
steroid receptors display genomic actions at the mitochondrial
chromosome, whereas membrane-bound receptors transmit metabolic effects
in the matrix or at the electron transport chain and modulate
mitochondrial structure and length or apoptosis.
Mitochondrial Hormone Receptors - an Emerging Field of Signaling in the Cell’s Powerhouse by Rüdiger Hardeland in BJSTR
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