#Microspheres for Cosmetic and Medical Injections Must be Free of Phagocytosable #Microparticles under 20 Microns by Gottfried Lemperle in BJSTR

#Microspheres for Cosmetic and Medical Injections Must be Free of Phagocytosable #Microparticles under 20 Microns by Gottfried Lemperle in BJSTR

Abstract

A more serious complication after the injection of all dermal fillers is the late occurrence of foreign body granulomas. The reason must be the retention of a foreign material in the memory of the macrophages, which likely had phagocytosed it years before a granuloma manifests itself as reddish-blue, dense nodules. This sudden granulomatous immune reaction is probably triggered by a sudden systemic bacterial infection which can be recalled by one-third of all granuloma patients. A vigorous removal of small PMMA particles < 20 μm in the only FDAapproved permanent injectable wrinkle filler ArteFill® and deep dermal injections, have decreased the granuloma rate from 0.5%, experienced with earlier-generation products of Artecoll® in Europe, to 0.01% (4 in 42,000 patients) in China when injected in the deep dermis.

https://biomedres.us/abstracts/BJSTR.MS.ID.000512.php 

https://biomedres.us/pdfs/BJSTR.MS.ID.000512.pdf 

https://biomedres.us/fulltexts/BJSTR.MS.ID.000512.php