Wednesday, October 31, 2018

#GastrointestinalAmyloidosis Manifesting as Chronic Diarrhea in a Case of #RheumatoidArthritis – A Case Report by Shefali Khanna Sharma in BJSTR

Abstract

Chronic inflammatory conditions like #RheumatoidArthritis (RA) causes deposition of #Amyloid Associated (AA) in various tissues or organs resulting in secondary or reactive systemic amyloidosis. We have reported here a 58-year old lady, known case of RA since 17 years with very poor compliance to treatment who presented with #chronicdiarrhea since 2 months, on evaluation, upper GI #endoscopy and #biopsy revealed positive for #serumamyloid associated on #innumohistochemistry staining, suggestive of secondary systemic amyloiosis. Symptoms gradually disappeared with the prompt institution disease modifying #anti-rheumaticdrugs (DMARDs). GI amyloidosis has been reported up to 60% of the patients with secondary amyloidosis and must not be forgotten while evaluating the cause for chronic diarrhea in a patient with #chronicinflammatorycondition like RA.




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