H2-calponin, an #actin-cytoskeleton associated protein, is expressed in
smooth muscle and certain non-muscle cells. Researchers have
demonstrated that H2-calponin proteins are highly expressed in
developing and remodeling tissues. As a mechanical tension responsive
gene
inside the cell, H2-calponin interacts with F-actin and certain focal
adhesion proteins, modifies #cytoskeleton function, takes part in
#mechanochemical
signal transmission and plays an important role in cell proliferation,
differentiation, motility and #cytokinesis. Based on recent research
progresses in this field, this paper reviewed the molecular
characteristics of H2-calponin and the role of H2-calponin in mechano
sensation and
mechano transduction.
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