Anti-Glycation and Glycation Reversing Potential of Fenugreek (Trigonella Foenum-Graecum) Seed Extract by WKSM Abeysekera in BJSTR

Abstract

Aim: To evaluate the #anti-glycation and #glycation reversing potential of fenugreek seed extract.

Methods: Freeze dried 70% ethanolic seed extract of fenugreek was used in this study. Anti-lycation and glycation reversing potential was studied in Bovine serum albumin (BSA)-glucose model. Antioxidant properties were studied using total #polyphenoliccontent, total #flavonoid content, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS),1,1-diphenyl-2-picrylhydrazine (DPPH) and ferric reducing #antioxidantpower (FRAP) in vitro antioxidant assays.

Results: The results demonstrated significant (P < 0.05) and dose dependant anti-glycation [IC50: (147.99±3.94) μg/mL] and glycation reversing activities [EC50:(553.37±8.02) μg/mL] and marked antioxidant properties [total polyphenolic content: (43.67±2.85) mg gallic acid equivalents/g of extract; total flavonoid content: (25.25±0.91) mg quercetin equivalents/g of extract; 2,2’-azino-bis(3-#ethylbenzothiazoline-6-sulfonicacid (ABTS), 1,1-diphenyl-2-picrylhydrazine (DPPH) and ferric reducing antioxidant power (FRAP): (35.45±0.32), (28.13±0.76) and (21.06±0.42) mg Trolox equivalents/g of extract, respectively].

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#Anti-Glycation and #Glycation Reversing Potential of Fenugreek (Trigonella Foenum-Graecum) Seed Extract by WKSM Abeysekera in BJSTR