Finite Element Stimulation Analysis on #OsteogenicCapacity of the Gelatin-Hybridized #CalciumPhosphate Cement by Noritaka Isogai in BJSTR

Abstract

When a bone defect is caused due to #craniotomy, skull reconstruction is performed with titanium plates or #hydroxyapatite in order to protect the brain and achieve an esthetically favorable outcome [1].These non-biodegradable #osteo-inducingmaterials remain in the body and are never incorporated into the auto logos bone. Skull reconstruction using these materials often evokes postoperative complication such as protrusion, #osteomyelitis, and instability. The use of biodegradable osteo-inducing #biomaterial that can be spontaneously changed to the antilogous bone would be ideal for skull reconstruction; however, such biomaterial has not been developed yet. We previously developed an inject able, biodegradable osteo-inducing biomaterial (gelatin-hybridized calcium phosphate cement, gelatin-hybridized CPC, Gunze Ltd., Kyoto, Japan), and demonstrated its estrogenic capacity using a rat model with a full-thickness skull defect. In the present study, we performed a histological analysis to investigate the influences of the degree of cross-linking and volume of gelatin contained within gelatin - hybridized CPC on the osteogenic capacity. Furthermore, we performed finite element simulation #analysis to examine the bone strength of the regenerated bone.

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Finite Element Stimulation Analysis on #OsteogenicCapacity of the Gelatin-Hybridized #CalciumPhosphate Cement by Noritaka Isogai in BJSTR