Abstract
In this study, two #polymethoxylflavones (PMFs), including #nobiletin
and #tangeretin, and one flavonoid, #hesperetin with one methoxyl
group, were investigated to inhibit lipid accumulation using 3T3-L1
adipocytes. The reducing lipid droplets of the three compounds at 50 μM
followed the order nobiletin=tangeretin>hesperetin; the inhibition of
triglyceride levels was in the order nobiletin> tangeretin>
hesperetin,
indicating the numbers of methoxyl groups on the benzene ring play an
important role in reducing #lipidaccumulation. These results imply
polymethoxylflavones with high degree of methoxylation are easily
permeable to cell membranes and demonstrate more regulating
#adipogenesis.
The findings of this study are useful for designing new v and is therefore a potentially lipid lowering compounds based on
chemical structure.
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