Abstract
Aims: The paper provided an effective way of analyzing #orofacialpain cases based on new findings in central and peripheral
sensitization.
Methods: The non-systematic review was undertaken by searching English literature in the PubMed by pertinent keywords. Case reports
and publications with weak levels of evidence were excluded.
Results: Central and #peripheralsensitizations affect the pain perception mainly in the way of changing levels of neurotransmitters, the
sensitivity of neurotransmitter receptors, #neurogenicinflammation, and malnutrition.
Discussion: Understanding the mechanism deeply in the view of #neurophysiology and molecular biology will be helpful for clinicians to
interpret orofacial pain symptoms efficiently and find treatment plans appropriately. A comprehensive table was provided.
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