#OxidativeDamage of Carotid Arteries in #DiabeticPatients by Ioannis Mamarelis in BJSTR

Abstract

In the present study, FT-IR spectra were used to study the carotid arteries of 20 #diabeticpatients. From the comparison of infrared spectra between insulin-dependent (type II) diabetic patients or diabetics on #oralhypoglycemicdrug treatment with the corresponding patient spectra having normal blood glucose levels, it was found that insulin-dependent(type II) diabetic patients showed more pronounced changes throughout the #absorption spectrum range (4000-800 cm-1). Particularly, the observed increase of the intensities of the stretching vibration bands of ethylene (vCH2) groups indicated that the #lipophilicenvironment of the membranes is significantly altered. This conclusion is attributed to the increase in the destructive effect of free radicals produced during oxidative stress in diabetics. Also from the shifts of the amide I and amide II absorption bands to lower frequencies it is concluded that the secondary structure of proteins has been changed from α-helix to β-sheet and random coil. The most significant changes were observed in the area where the C-O-C groups of sugars and C-O-P-O sugar-phosphate groups of DNA and #phospholipids absorb as a result of the disease.

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#OxidativeDamage of Carotid Arteries in #DiabeticPatients by Ioannis Mamarelis in BJSTR