Abstract
An 89-year-old man was admitted to our service for worsening
#asthenia and #dyspnea over a period of 3 weeks. His history was
positive for arterial hypertension, ischemic heart disease, and lowgrade
non-Hodgkin’s lymphoma (#lymphoplasmacyticlymphoma)
treated with #chemotherapy consisting of rituximab, #prednisone,
doxorubicin, #cyclophosphamide and vincristine (R-CHOP).
Moreover, he suffered multiple episodes of cold agglutinin anaemia
secondary to lymphoma. Routine laboratory showed mild anemia
(haemoglobin of 7.6 g/dl); the remainder of his laboratory
evaluation was within normal limits apart from mild deficiency
of folic acid and vitamin B-12. Because of his cardiac condition
transfusion threshold was set at 8.0 g/dl and blood transfusion was
ordered. Patient’s group was O Rh+. The hospital blood transfusion
laboratory detected the presence of #coldagglutinins. The nurse
routinely verified recipient’s and donor’s group at the patient’s
bedside prior to transfusion.
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#ColdAgglutinin Disease: A Flash, Bedside Card, Diagnosis by Matteo Coen in BJSTR
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